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rGH injection natural hormone release

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理解问题rGH injection natural hormone release

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Rat growth hormone (rGH) injection is used as a positive control in studies to evaluate the release of growth hormone in rats. After an intravenous injection of rGH, the time to reach the maximum plasma rGH level, denoted as $ T_{max} $, is observed1。This indicates that rGH injection can effectively stimulate the release of the natural hormone in the test subjects.

Recombinant human growth hormone (rhGH) is a therapeutic agent used to treat various conditions related to growth hormone deficiency. However, due to its poor bioavailability and short half-life, it typically requires daily injections. Recent advancements have led to the development of sustained-release formulations of rhGH, such as DA-3003, which can maintain elevated plasma concentrations for an extended period, reducing the need for daily injections2。This development is significant as it addresses the challenges associated with the frequent administration of the hormone.

The hypothalamic hormones, growth hormone-releasing hormone (GHRH) and somatostatin, play a crucial role in the regulation of growth hormone release7。GHRH positively regulates the release, while somatostatin negatively regulates it. This intricate balance ensures the proper functioning of the growth hormone within the body.

In summary, rGH injection serves as a positive control to study natural hormone release, and advancements in sustained-release formulations of rhGH, such as DA-3003, offer potential solutions to reduce the frequency of injections needed for effective treatment23。The regulation of growth hormone release is a complex process involving multiple hypothalamic hormones, ensuring the hormone's proper function within the body7

What are the potential side effects of daily rhGH injections compared to the sustained-release formulation?

Daily recombinant human growth hormone (rhGH) injections are currently approved for use in children and adults with growth hormone deficiency (GHD) in many countries and are known to have relatively few side effects.81114 However, the sustained-release formulation of rhGH, such as DA-3003, has been developed to potentially offer a safer and more efficacious alternative with a weekly dosing regimen.2 Studies have shown that the sustained-release formulation did not result in the development of antibodies to hGH, indicating a safety profile comparable to that observed with daily rhGH injections.2 Additionally, there were no significant differences in efficacy between daily injections and the sustained-release formulation in hypophysectomized rats, as assessed by changes in body weight and the width of the tibial growth plate.2 However, it is important to note that while some long-acting growth hormone (LAGH) preparations have shown non-inferiority compared to daily rhGH for improved height velocity, others have been found inferior for growth velocity and body composition.91516

How does the pulsatile secretion of hGH during sleep affect its therapeutic use in patients with GHD?

Human growth hormone (hGH) is naturally secreted in a pulsatile fashion, predominantly during sleep, which is crucial for its physiological effects.718 This pulsatile secretion is regulated by the hypothalamic hormones growth hormone-releasing hormone (GHRH) and somatostatin.7 The therapeutic use of rhGH in patients with GHD aims to mimic the body's natural secretion pattern as closely as possible to ensure optimal efficacy.18 The sustained-release formulation of rhGH, such as DA-3003, has been designed to provide a more prolonged and stable hormone level in the body, potentially better mimicking the natural pulsatility of hGH secretion during sleep.2 This approach may offer therapeutic advantages by maintaining physiological hormone levels for an extended period, thus potentially improving treatment outcomes in patients with GHD.

What is the role of zinc oxide and hydroxypropyl-β-cyclodextrin in the sustained-release formulation of rhGH?

Zinc oxide and hydroxypropyl-β-cyclodextrin (HPCD) play essential roles in the sustained-release formulation of rhGH, such as DA-3003.2 Zinc oxide acts as a release modulator, helping to control the rate at which the rhGH is released from the formulation over time.2 On the other hand, HPCD serves as a stabilizer and aggregation-prevention agent, ensuring the stability of the rhGH and preventing it from aggregating, which could otherwise affect its efficacy and safety.2 The combination of these two components contributes to the development of a formulation that can sustain the elevated concentration of rhGH in plasma for an extended period, such as 14 days in rats and 28 days in monkeys, after a single administration.2

How does the bioavailability of rhGH compare to that of the sustained-release formulation, and what are the implications for dosing frequency?

The bioavailability of rhGH when administered as a daily injection is relatively poor, necessitating frequent dosing to maintain therapeutic levels.137 In contrast, the sustained-release formulation of rhGH, such as DA-3003, has been specifically designed to enhance bioavailability and extend the duration of action.2 After a single administration of DA-3003, the elevated concentration of rhGH in plasma was sustained for 14 days in rats and 28 days in monkeys, significantly reducing the dosing frequency compared to daily injections.2 This extended release has the potential to improve patient compliance and convenience, as well as maintain more stable hormone levels, which could lead to better therapeutic outcomes.

What are the pharmacodynamic markers used to assess the efficacy of rhGH administration, and how do they differ between daily injections and sustained-release formulations?

Pharmacodynamic markers are used to evaluate the biological effects of a drug on its target.3940 In the context of rhGH administration, insulin-like growth factor-1 (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) are key pharmacodynamic markers that indicate the efficacy of rhGH treatment.2 These markers have been used to assess the effects of both daily injections and sustained-release formulations

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相关内容13

Intravenous injection of rat growth hormone releasing hormone (rGH)1

rGH注射实验 研究了大鼠生长激素释放激素(rGH)的血浆水平。

Sustained-release formulation of rhGH (SR-rhGH), DA-30032

SR-rhGH研究 开发了一种持续释放的重组人生长激素(rhGH)配方,DA-3003。

Formulation of sustained-release rhGH for two months using mPEG-PLA, PELA3

持续释放rhGH 研究了使用mPEG-PLA, PELA的两个月持续释放rhGH配方。

Recombinant human growth hormone (rhGH) application4

rhGH应用 重组人生长激素(rhGH)在临床和研究中的应用。

Puerariae Radix, Flos, and Surculus induction of rat growth hormone (rGH) release6

植物成分诱导rGH释放 研究了Puerariae Radix等植物成分对大鼠生长激素释放的影响。

Regulation of release by hypothalamic hormones7

下丘脑激素调节 研究了下丘脑激素对生长激素释放的正负调节。

growth hormone-releasing hormone (GHRH)7

GHRH Regulation GHRH regulates the release of natural growth hormone by positive feedback.

somatostatin7

Somatostatin Regulation Somatostatin negatively regulates the release of natural growth hormone.

rat growth hormone releasing hormone (rGHRH)1

rGH注射影响 rGHRH作为阳性对照,通过静脉注射影响大鼠体内生长激素的释放。

recombinant human growth hormone (rhGH)2

rhGH疗法 用于治疗矮小症,需每日注射,研究开发了SR-rhGH以实现持续释放。

insulin-like growth factor-1 (IGF-I)2

药效学标记 IGF-I作为rhGH给药的药效学标记,其浓度在DA-3003给药后持续升高。

insulin-like growth factor binding protein-3 (IGFBP-3)2

药效学标记 IGFBP-3同样作为rhGH给药的药效学标记,其浓度在DA-3003给药后持续升高。

growth hormone-releasing hormone (GHRH)7

生长激素释放激素 GHRH是下丘脑激素,正向调节生长激素的释放。

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